De Rossi, who has spent 18 seasons with I Giallorossi, has established himself as a club legend, making a total of 615 appearances down the years.
But the 35-year-old will look for challenges outside of Rome ahead of the 2019/20 campaign.
The Series A outfit broke the news on Tuesday morning, revealing the long-serving midfielder will emotionally leave the club at the end of the campaign after his last match against Parma.
‘For 18 years, Daniele has been the beating heart of AS Roma’s team,’ club president James Pallotta told the club’s official website.
‘From his debut in 2001 to taking on the responsibility of the captain’s armband, he always represented the Roma fans on the pitch with pride as he established himself as one of the best midfielders in Europe.
‘We will all shed tears when he pulls on the Giallorossi shirt for the last time against Parma but we respect his desire to prolong his playing career – even if, at almost 36, it will be away from Rome.
‘On behalf of everyone at Roma, I’d like to thank Daniele for his incredible dedication to this club and ensure him that our doors will remain open for him to return to the club in a new role whenever he wants.’
De Rossi who joined Roma as a teenager back in 2000, before going on to make his first-team debut a year later has scored 63 goals, as well as winning two Coppa Italia titles and a Supercoppa for the club.
DE ROSSI AT ROMA:
Coppa Italia: 2007 & 2008